Mps1Mph1 kinase phosphorylates Mad3 to inhibit Cdc20Slp1-APC/C and maintain spindle checkpoint arrests
Hardwick lab paper featured in PLoS Genetics.
Authors
Zich J., May K., Paraskevopoulos K., Sen O., Syred H.M., van der Sar S.J., Patel H., Moresco J.L., Sarkeshik A., Yates III J.R., Rappsilber J., and Hardwick K.G.
Summary
The Hardwick group show that Mps1 kinase-dependent modification of Mad3 and Mad2 acts to delay cell division in situations where a cell's genetic material would not be equally inherited by daughter cells.