Transcription-coupled changes to chromatin underpin gene silencing by transcriptional interference
Allshire lab paper featured in Nucleic Acids Research.
Authors
Ard, R. and Allshire. R.C.
Summary
We demonstrate that transcriptional interference of the tgp1+ and pho1+ genes involves transcription-coupled chromatin changes mediated by conserved elongation factors Set2, Clr6CII, Spt6 and FACT that travel with RNAPII. Given that eukaryotic genomes are pervasively transcribed, transcriptional interference likely represents a more general feature of gene regulation than is currently appreciated.