G9a/GLP complex maintains imprinted DNA methylation in embryonic stem cells
Rappsilber lab paper featured in Cell Reports.
Authors
Zhang, T., Termanis, A., Ozkan, B., Bao, X.X., Culley, J., de Lima Alves, F., Rappsilber, J., Ramsahoye, B. and Stancheva, I.
Summary
In this study Zhang et al. show that the G9a/GLP complex of histone methylases stabilize imprinted DNA methylation in embryonic stem cells by recruitment of de novo DNA methyltransferase enzymes, which counteract TET dioxygenase-dependent demethylation pathways.