Strand-specific, high-resolution mapping of modified RNA polymerase II
Tollervey lab paper featured in Molecular Systems Biology.
Authors
Milligan, L., Huynh-Thu, V.A., Delan-Forino, C., Tuck, A., Petfalski, E., Lombraña, R., Sanguinetti, G., Kudla, G. and Tollervey, D.
Summary
A new technique for transcriptome‐wide mapping of RNAPII carrying the five types of CTD phosphorylation is presented. Distinct modification states associated with initiating, early and late elongating RNAPII are identified using a hidden Markov model.
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