Tissue-specific gene repositioning by muscle nuclear membrane proteins enhances repression of critical developmental genes during myogenesis
Schirmer lab paper featured in Molecular Cell.
Authors
Robson, M.I., de Las Heras, J.I., Czapiewski, R., Le Thanh, P., Booth, D.G., Kelly, D.A., Webb, S., Kerr, A.R., and Schirmer, E.C.
Summary
Muscle-specific nuclear envelope transmembrane proteins (NETs) were shown to specifically direct the repositioning of genes to the nuclear periphery during myogenesis where the peripheral positioning roughly doubles the amount of gene repression. Genes so regulated require tight temporal regulation during differentiation and accordingly combined knockdown of these NETs blocks muscle differentiation.