Reductional meiosis I chromosome segregation is established by coordination of key meiotic kinases
Marston lab paper featured in Developmental Cell.
Authors
Galander, S., Barton, R.E., Borek, W.E., Spanos, C., Kelly, D.A., Robertson, D., Rappsilber, J. and Marston, A.L.
Summary
Uniquely during meiosis I, homologs, rather than sister chromatids, are segregated. Galander et al. show that the meiosis I-specific Spo13 protein prevents sister chromatid segregation by controlling the effects of multiple kinases to both enforce sister kinetochore co-orientation and prevent premature loss of cohesion.