Aurora B kinase disrupts the extended conformation of lattice-bound Kinesin-13 MCAK
Welburn lab paper featured in Journal of Cell Science.
Authors
McHugh, T., Zou, J., Volkov, V., Bertin, A., Rappsilber, J., Dogterom, M., Welburn, J.P.I.
Summary
The kinesin-13 MCAK has a compact conformation in solution but is extended when bound to microtubules. Aurora B AQ23 phosphorylation of MCAK inhibits depolymerase activity by disrupting its extended conformation.