Host Vesicle Fusion Protein VAPB Contributes to the Nuclear Egress Stage of Herpes Simplex Virus Type-1 (HSV-1) Replication
Schirmer lab paper featured in Cells.
Authors
Saiz-Ros, N., Czapiewski, R., Epifano, I., Stevenson, A., Swanson, S.K., Dixon, C.R., Zamora, D.B., McElwee, M., Vijayakrishnan, S., Richardson, C.A., Dong, L,, Kelly, D.A., Pytowski, L., Goldberg, M.W., Florens, L., Graham, S.V., Schirmer, E.C..
Summary
The least mechanistically understood aspect of herpes simplex virus infection is how virus particles — too large to go through the nuclear pore complexes — escape the nucleus. Saiz-Ros and colleagues show that host cell vesicle fusion protein VAPB is important for this process with virus particles accumulating in the nucleus upon VAPB knockdown (left) and infectious virus titers dropping upon VAPB knockdown >10-fold (right).