Borealin-nucleosome interaction secures chromosome association of the chromosomal passenger complex
Jeyaprakash lab paper featured in the Journal of Cell Biology.
Authors
Abad, M.A., Ruppert, J.G., Buzuk, L., Wear, M., Zou, J., Webb, K.M., Kelly, D.A., Voigt, P., Rappsilber, J., William C. Earnshaw, W.C., Jeyaprakash, A.A.
Summary
Abad et al. report that the chromosomal passenger complex (CPC), an essential regulator of error-free chromosome segregation, is targeted to chromosomes via Borealin-mediated direct interaction with nucleosomes. This is critical for subsequent histone modification–dependent centromere enrichment and function of the CPC during metaphase.