Interspecies conservation of organisation and function between nonhomologous regional centromeres
Allshire lab paper featured in Nature Communications.
Authors
Pin Tong, Pidoux, A.L., Toda, N.R.T., Ard, R., Harald Berger, H., Manu Shukla, M., Torres-Garcia, J., Carolin A. Müller, C.A., Nieduszynski, C.A. & Allshire, R.C.
Summary
Although the centromere-specific histone CENP-A usually assembles on specific genomic sequences, centromeric DNA is not conserved. Here the Allshire Lab characterise the genome and centromeres of related fission yeasts and provide evidence that Schizosaccharomyces centromere DNA possesses intrinsic conserved properties that promote assembly of CENP-A chromatin.