Lin28a regulates neuronal differentiation and controls miR-9 production
Rappsilber lab paper featured in Nature Communications.
Authors
Jakub S. Nowak, Nila Roy Choudhury, Flavia de Lima Alves, Juri Rappsilber and Gracjan Michlewski
Summary
MicroRNAs regulate gene expression and control cell fate and differentiation processes. In this work, Nowak et al. reveal that brain-specific miR-9 is under post-transcriptional control and that the pre-miR-9 binding protein Lin28a decreases the levels of mature miR-9 during retinoic acid-mediated neuronal differentiation.