A splicing-dependent transcriptional checkpoint associated with pre-spliceosome formation
Beggs lab paper featured in Molecular Cell.
Authors
Keerthi T. Chathoth, J. David Barrass, Shaun Webb and Jean D. Beggs
Summary
Transcriptional elongation is inhibited when cotranscriptional pre-spliceosome formation is blocked. The defect is characterised by RNA polymerase with hyperphosphorylated Serine 5 (red P) on the CTD accumulating on introns.