Long non-coding RNA-mediated transcriptional interference of a permease gene confers drug tolerance in fission yeast
Allshire lab paper featured in Nature Communications.
Authors
R. Ard, P. Tong, R. C. Allshire
Summary
The presence of long non-coding RNAs (lncRNAs) is pervasive across genomes, yet few lncRNAs have clearly established mechanisms of action. Here the authors demonstrate that the fission yeast lncRNA nc-tgp1 governs drug tolerance via transcriptional interference of a permease gene.