Genome-wide distribution of RNA-DNA hybrids identifies RNase H targets in tRNA genes, retrotransposons and mitochondria
Tollervey lab paper featured in PLoS Genetics.
Authors
El Hage, A., Webb, S., Kerr, A. and Tollervey D.
Summary
The foreground shows the transcribing RNA polymerase with an R-loop forming between the nascent transcript and the DNA. In the Ty1 pre-integration complex two integrase molecules (colored in pink) target nucleosomes upstream of tRNA genes. Three left-handed arrows indicate potential interactions between the R-loop and Ty1 pre-integration complex.