Trim25 Is an RNA-Specific Activator of Lin28a/TuT4-Mediated Uridylation
Centre lab paper featured in Cell Reports.
Authors
Nila Roy Choudhury, Jakub S. Nowak, Juan Zuo, Juri Rappsilber, Steven H. Spoel and Gracjan Michlewski
Summary
Lin28a triggers TuT4-mediated pre-let-7 uridylation. Despite binding to other pre-microRNAs, only pre-let-7 is efficiently uridylated by TuT4. Choudhury et al. show that Trim25 is an RNA-specific cofactor for Lin28a/TuT4-mediated uridylation. These findings reveal that Trim25 can guide the function of canonical RNP complexes in cis , thereby providing an additional level of specificity.