A pathway for mitotic chromosome formation
Earnshaw lab paper featured in Science.
Authors
Gibcus, J.H., Samejima, K., Goloborodko, A., Samejima, I., Naumova, N., Nuebler, J., Kanemaki, M.T., Xie, L., Paulson, J.R., Earnshaw,W.C., Mirny,L.A., Dekker, J.
Summary
In this paper we integrate genetic, genomic and computational approaches to characterize the key steps in mitotic chromosome formation from the G2 nucleus to metaphase, and identify roles of specific molecular machines, condensin I and II, in these major conformational transitions.