Systematic analysis of compounds specifically targeting telomeres and telomerase for clinical implications in cancer therapy
Earnshaw lab paper featured in CancerResearch Journal.
Authors
Lee, H-S., Carmena, M., Liskovykh, M., Peat, E., Kim, J-H., Oshimura, M., Masumoto, H.,Teulade-Fichou, M-P., Pommier, Y., Earnshaw, W.C., Larionov, V., and Kouprina, N.
Cancer Research 2018 78:6282-6296
Summary
A novel screen that allows the quantification of chromosome loss of HACs (Human Artificial Chromosomes) identified inhibitors of telomerase function that induce high rate of aneuploidy. Using immunofluorescence we characterised the defects in mitosis induced by the identified telomerase inhibitors: these include chromatin bridges and Ultrafine Bridges. Our approach may expedite the development of new therapeutic strategies for cancer treatment.