The C-terminal region of MCAK controls its activity and structure through a major conformational switch
Welburn lab paper featured in eLife.
Authors
Talapatra S., Harker B., Welburn JPI.
Summary
Structural analysis of the kinesin-13 MCAK bound to its C-terminal tail reveals the molecular basis for the conformation of kinesin-13 in solution and the mechanism that triggers long-range conformational changes upon microtubule binding.