14-3-3 regulation of Ncd reveals a new mechanism for targeting proteins to the spindle in oocytes
Ohkura lab paper featured in the Journal of Cell Biology.
Authors
Beaven, R., Nunes Bastos, R., Spanos, C., Romé, P., Cullen, C.F., Rappsilber, J., Giet, R., Goshima, G. and Ohkura, H.
Summary
14-3-3 interacts with the kinesin-14 Ncd and prevents it from binding microtubules. Aurora B provides a spatial cue that releases Ncd from 14-3-3 around chromosomes, allowing Ncd to selectively bind the spindle microtubules in the large volume of oocytes.