Pervasive coexpression of spatially proximal genes is buffered at the protein level
Rappsilber lab paper featured in Molecular Systems Biology.
Authors
Kustatscher, G., Grabowski, P., Rappsilber, J.
Summary
Housekeeping genes are clustered in the human genome, which minimizes stochastic silencing but leads to partial coexpression of thousands of functionally unrelated genes. This non‐functional mRNA coexpression is buffered at the protein level.