A yeast exosome cofactor, Mpp6, functions in RNA surveillance and in the degradation of noncoding RNA transcripts

Tollervey lab paper featured in Molecular and Cellular Biology.

Image from Tollervey paper, Molecular and Cell Biology 2008 — Figure: Two aspects of ncRNA are likely to contribute to rapid degradation: (Left) Some exosome cofactors bind nascent RNA, "pretargeting" it for degradation as soon as the 3' end is released from the transcribing polymerase; (Right) Multiple, partially redundant cofactors target the ncRNA for degradation.

Authors

Milligan L, Decourty L, Saveanu C, Rappsilber J, Ceulemans H, Jacquier A, Tollervey D.

Molecular and Cellular Biology 28(17): 5446-5457, September 2008

Summary

The exosome complex depends on different cofactors for in vivo RNA degradation activity. In an attempt to identify novel exosome cofactors, the Tollervey lab performed a genome-wide screen for synthetic lethal interactions with nuclear exosome cofactors Rrp47 or Air1. This identified Mpp6, a novel exosome cofactor involved in RNA surveillance of pre-rRNA and pre-mRNA. Mpp6 together with other exosome cofactors also targets noncoding RNAs for degradation.

A yeast exosome cofactor, Mpp6, functions in RNA surveillance and in the degradation of noncoding RNA transcripts

Authors

Summary

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