A role for Q/N-rich aggregation-prone regions in P-body localization
Beggs lab paper featured in the Journal of Cell Science.
Authors
Reijns MA, Alexander RD, Spiller MP, Beggs JD.
Journal of Cell Science 121 (15): 2463-2472
Summary
P-bodies are cytoplasmic mRNA-processing foci containing a variety of RNA-degradation factors. In this study the Beggs lab shows that efficient accumulation of RNA-degradation factors in P-bodies is promoted by regions rich in glutamine and/or asparagine (Q/N rich regions). The presence of these regions in other P-body components suggests a possible general role in localization and assembly of P-bodies.