Specific nuclear envelope transmembrane proteins can promote the location of chromosomes to and from the nuclear periphery
Schirmer lab paper featured in Genome Biology.
Authors
Zuleger N, Boyle S, Kelly DA, de Las Heras JI, Lazou V, Korfali N, Batrakou DG, Randles KN, Morris GE, Harrison DJ, Bickmore WA, Schirmer EC.
Summary
Tissue-specific patterns of spatial genome organisation are postulated to contribute to gene regulation, but, because the proteins directing this were unknown, studies had to rely on artificial systems that gave conflicting results. This study has identified many tissue-specific nuclear envelope proteins that direct spatial genome organisation and sets the stage to finally get an unequivocal answer to the functional role of spatial cues. The image shows a nuclear envelope transmembrane protein recruiting chromosome 5 to the periphery.
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