Splicing-dependent RNA polymerase pausing in yeast
Beggs lab paper featured in Molecular Cell.
Authors
Alexander RD, Innocente SA, Barrass JD, Beggs JD.
Summary
In eukaryotic organisms, there is evidence for functional coupling between transcription and processing of pre-mRNAs, with many RNA processing events occurring cotranscriptionally. In this article the Beggs lab present evidence that RNA polymerase accumulates transiently and repeatedly in a splicing-dependent manner near the 3' ends of introns in budding yeast. This suggests that RNA polymerase pauses while splicing takes place cotranscriptionally on at least some budding yeast genes. The cover image is a cartoon depicting RNA polymerase as a train loaded with RNA processing factors, stopping for splicing to take place. The artwork is by Christina Barrass, a 15-year old art and design student.
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