Herpes simplex virus ICP27 protein directly interacts with the nuclear pore complex through Nup62, inhibiting host nucleocytoplasmic transport pathways
Schirmer lab paper featured in Journal of Biological Chemistry.
Authors
Malik P, Tabarraei A, Kehlenbach RH, Korfali N, Iwasawa R, Graham SV, Schirmer EC.
Summary
Herpesviruses block host cell transport into the nucleus through herpes-encoded ICP27 binding to nuclear pore complex protein Nup62. The image shows ICP27 preventing nuclear translocation of a GFP reporter construct.
PMID: 22334672