The nuclear envelope proteome differs notably between tissues
Schirmer lab paper featured in Nucleus.
Authors
Korfali N, Wilkie GS, Swanson SK, Srsen V, de Las Heras J, Batrakou DG, Malik P, Zuleger N, Kerr AR, Florens L, Schirmer EC.
Summary
Proteomic studies of the nuclear envelope from liver, muscle and blood leukocytes have revealed that the majority of nuclear envelope proteins are tissue-specific or tissue-restricted. Such proteins could explain the tissue-specific pathologies in nuclear envelope linked disease. The image is a heat map showing that many nuclear envelope proteins were found in only one tissue.
PMID: 22990521