Cdc55 coordinates spindle assembly and chromosome disjunction during meiosis
Marston lab paper featured in the Journal of Cell Biology.
Authors
Farid Bizzari and Adele L. Marston
Summary
Meiosis is the cell division that generates gametes, such as eggs and sperm. Errors in meiosis can generate gametes with the wrong number of chromosomes and this causes infertility and birth defects. In this article, the Marston lab have used budding yeast as a model to demonstrate that a phosphatase regulatory subunit, Cdc55, is essential to control the activity of two further phosphatases during meiosis. They show that the coordinated action of these three phosphatases is essential to ensure accurate segregation of the chromosomes to produce functional gametes.