Shugoshin prevents cohesin cleavage by PP2ACdc55-dependent inhibition of separase.
Marston lab paper featured in Genes and Development.
Authors
Dean Clift, Farid Bizzari and Adele L. Marston
Genes and Development, 23: 766-780. March 2009-05-04.
Summary
The Marston lab investigated the mechanism by which the protector protein Shugoshin counteracts cohesin cleavage in budding yeast. This work identified a novel pathway for separase inhibition.