Yuxiao Chen

Undergraduate Research Student, CRM, Institute for Regeneration and Repair, University of Edinburgh

Biography

Background

2026.1-Present: Undergraduate Research Student, Systematic Aging Lab (Dr. Yifan Yang), CLS, Westlake University

2025.8-2025.12: Undergraduate Research Student, Soufi Group, CRM, Institute for Regeneration and Repair (IRR), The University of Edinburgh

2023.8–Present: Undergraduate Research Student, Cell Fate Control Lab (Prof. Duanqing Pei), SLS, Westlake University

2023–2027: BSc in Biology (in progress), Westlake University, China

Research summary

3D Genome Architecture — Investigating how higher-order chromatin organization contributes to the regulation of cell fate, with a particular focus on heterochromatin clustering and its role in stabilizing multipotent genome structure.

Chromatin Accessibility — Exploring how chromatin regulators and transcription factors shape accessible regulatory landscapes to control gene networks.

Totipotency–Pluripotency Transition — Studying the mechanisms by which totipotent loci are released from repressive structures, and developing approaches to reset pluripotent cells into totipotent-like states.

Project activity

Fu Y, Ma W, Han J, Zhang W, Zhang S, Chen Y, Qin Y, Li J, Zhai Z, Li P, Li W, Wang K, Ma Z, Yao Y, Zhao C, Wang B, Chai H, Ruan Y, Kuang J, Zhang Z, Pei D, Topologically Associating Domains Define the 3D Genome Architecture of Mouse Totipotent-like Stem Cells, Journal of Biological Chemistry (2026)

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