Tom Chambers

Clinical Lecturer

  • Centre for Cardiovascular Science
  • Centre for Discovery Brain Science

Contact details

Address

Street

Room 171
Hugh Robson Building
15 George Square
EDINBURGH

City
Post code
EH8 9XD

Biography

Background

I am a SCREDS clinical lecturer. I am currently undertaking an ISSF research leave fellowship before returing to complete the final year of my training in diabetes and endocrinology. I developed an interest in endocrinology as a medical student; during my intercalated MRes year, I studied Wnt induced plasticity in the lactotroph population of the pituitary gland in response to oestrogen.

 

Following completing core medical training in Manchester, I moved to Edinburgh to undertake a PhD looking at the intergenerational effects of high fat diet exposure focusing on epigentic and transcriptional regulation of the male germ line.

 

I took up the SCREDS clinical lectureship in 2017 and am developing clincal and basic research to improve our understanding of the recovery and plasticity of the hypothalamus-pituitary-adrenal axis in response to exogenous steroid treatment and withdrawal.

Qualifications

BSc Medical Science

MB ChB

MRes Medical Science

PhD Reproductive health

MRCP

Current research interests

Recovery of the hypothalamus pituitary adrenal (HPA) axis following steroid treatment: 1. Modelling recovery of the HPA axis in vitro (using AtT-20 cell line) and in vivo 2. Plasticity in corticotrophins in response to glucocorticoid 3. Predicting HPA axis recovery in patients following chronic glucocorticoid treatment; developing biomarkers to identify patients at risk of adrenal insufficiency

Past research interests

Lactotroph plasticity/ Wnt signaling in the pituitary. Intergenerational effects of environmental exposures.

Current project grants

ISSF3 research leave fellowship August 2019- Feb 2020: Modelling glucocorticoid induced adrenal insufficiency to inform mechanisms
MRC CiC August 2018 - Sept 2019: Development for a novel assay to detect glucocorticoid induced adrenal insufficiency

This article was published on