Professor Dusan Uhrin
Chair of NMR Spectroscopy
Contact details
- Tel: 0131 650 4742
- Email: dusan.uhrin@ed.ac.uk
- Web: Uhrin Group Website
Address
- Street
-
Room 270
University of Edinburgh
Joseph Black Building
David Brewster Road
Edinburgh
EH9 3FJ - City
- Post code
Research summary
NMR spectroscopy, NMR methodology development, complex mixtures analysis
Research Overview
New NMR Methodology
Using 60 to 800 MHz NMR spectrometers, many equipped with CryoProbesTM, we are developing liquid-state NMR methodology for diverse branches of science. In particular, we work on increasing the sensitivity of NMR spectroscopy. Recent application of our SHARPER NMR concetp9,1,2 has seen up to 30-fold sensitivity improvement of benchtop NMR.1
Complex Mixtures
The structure elucidation of compounds contained within complex mixtures is a challenging task. We study various mixtures such as those fund in the environment, living organisms or food and beverages, e.g. Scotch whisky.5,6,8 Using metabolomics approaches,4 we collaborate with colleagues in biology, agriculture and medicine.
- Dickson, C.L., Peat, G. Rossetto, M., Halse, M.E. and Uhrín, D., SHARPER-enhanced benchtop NMR: improving SNR by removing couplings and approaching natural linewidths, Chem. Commun., 58, 5534-5537 (2022).
- Davy, M., Dickson, C.L., Wei, R., Uhrín, D., Butts, C.P. Monitoring off-resonance signals with SHARPER NMR – the MR-SHARPER experiment, Analyst, 147, 1702-1708 (2022).
- Wei, R., Dickson, C.L., Uhrín, D., Lloyd-Jones, G.C. Rapid Estimation of T1 for Quantitative NMR J. Org. Chem. 86 9023–9029 (2021).
- Bica, R., Palarea-Albaladejo, J., Kew, W., Uhrín, D, Pacheco, D., Macrae, A., Dewhurst, R.J. Nuclear Magnetic Resonance to Detect Rumen Metabolites Associated with Enteric Methane Emissions from Beef Cattle, Sci Rep, 10, 5578 (2020.
- Stockwell, M., Goodall, I. Uhrín, D, Quantification of whisky congeners by 1H NMR spectroscopy, Anal. Sci. Adv. 1,132–140(2020).
- Kew, W., Goodall, I., Uhrín, D. Analysis of Scotch Whisky by 1H NMR and chemometrics yields insight into its complex chemistry, Food Chemistry. 298, 125052 (2019).
- Brodaczewska, N., Košťálová, Z. Uhrín, D, (3, 2)D 1H, 13C BIRDr,X-HSQC-TOCSY for NMR structure elucidation of mixtures. Application to complex carbohydrates, J Biomol. NMR 70,115–122 (2018).
- Kew, W., Bell, N.G.A. Goodall, I., Uhrín, D, Advanced solvent signal suppression for the acquisition of 1D and 2D NMR spectra of Scotch Whisky, Magn. Reson. Chem. 55, 785–796, (2017).
- Jones, A.B., Lloyd-Jones, G.C., Uhrín, D, SHARPER reaction monitoring: generation of a narrow line-width NMR singlet, without X-pulses, in an inhomogeneous magnetic field, Anal. Chem. 89 10013–10021 (2017).