Dr Shaden Melhem (PhD, MSc, BSc)

Postdoctoral Research Fellow

  • University of Edinburgh

Contact details

Address

Street

Institute for Regeneration & Repair
Edinburgh BioQuarter
4-5 Little France Drive

City
Post code
EH16 4UU
Street

Institute for Regeneration and Repair (IRR) 

City
4-5 Little France
Post code
EH16 4UU

Biography

Background

I am a Postdoctoral Researcher at the University of Edinburgh, based within the Institute for Regeneration and Repair. My research focuses on endocrine and metabolic biology, with particular expertise in quantitative steroid analysis using LC–MS/MS, hormone metabolism, metabolomics, and translational disease modelling. I completed my PhD in Cardiovascular Science at the University of Edinburgh in 2025, where I investigated the role of thiosulfate sulfurtransferase (TST) in metabolic dysfunction-associated steatotic liver disease (MASLD), calorie restriction, and metabolic health.

My work combines analytical chemistry, endocrinology, and systems biology approaches to investigate how metabolic and hormonal pathways contribute to human disease. I have experience working with in vivo mouse models, human and immortalised cell culture systems, metabolomics, and mass spectrometry imaging (MSI), alongside advanced quantitative LC–MS/MS method development and validation.

I am currently involved in an international collaborative project between the University of Edinburgh and the Massachusetts Institute of Technology (MIT), developing human endometrial microphysiological models to study steroid hormone dynamics and tissue-specific metabolism. Alongside research, I have contributed to undergraduate teaching in endocrinology and biochemistry and held a UK Home Office Personal Licence (Modules A–C) for animal research.

Qualifications

  • PhD in Cardiovascular Science, University of Edinburgh (2025)
  • MRes in Cardiovascular Science (Distinction), University of Edinburgh (2021)
  • MRes in Medical and Molecular Biosciences, Newcastle University (2017)
  • BSc in Biology (Pre-Medical), Very Good (83%), Bard College (2014)
  • UK Home Office Personal Licence (Modules A–C) Certified for in vivo animal research procedures in the United Kingdom.

Affiliated research centres

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