Dr Josselin Nespoux (Ph.D.)

Postdoctoral Research Fellow

Contact details

Address

Street

Centre for Cardiovascular Science
Queen's Medical Research Institute
Edinburgh BioQuarter
47 Little France Crescent

City
Edinburgh
Post code
EH16 4TJ

Biography

Background

Josselin Nespoux is an early-career renal physiologist with training from Université de Poitiers, University of Utah, University of California San Diego, and University of Edinburgh. Dr. Nespoux is currently a Postdoctoral Research Fellow at the Centre for Cardiovascular Science, Edinburgh, where he conducts research aiming at better understanding the interplay between renal, vascular and immune systems in health and disease. Dr. Nespoux works under the supervision of Pr. Neeraj Dhaun and Pr. Matt Bailey.

Research summary

Renal physiology, hypertension and chronic kidney disease (CKD)

Current research interests

The interplay between immune, renal and vascular systems in the pathogenesis of hypertension and cardiovascular disease --- Retinal imaging in mice as a tool for understanding microvascular health in kidney disease --- The role of leucine-rich alpha-2 glycoprotein 1 (LRG1) in the pathogenesis of acute and chronic kidney diseases

Past research interests

The purinergic P2X7 receptor in renal haemodynamics physiology, and kidney inflammation and injury --- Glucose transport in acute kidney injury (AKI)

Expression of leptin receptor in renal tubules is sparse but implicated in leptin-dependent kidney gene expression and function.

Kim YC, Fattah H, Fu Y, Nespoux J, Vallon V.

Am J Physiol Renal Physiol. 2023 Jun 1;324(6):F544-F557. doi:10.1152/ajprenal.00279.2022. Epub 2023 Apr 27. PMID: 37102688

 

Western Diet Promotes Renal Injury, Inflammation, and Fibrosis in a Murine Model of Alström Syndrome.

Kim YC, Ganguly S, Nespoux J, Freeman B, Zhang H, Brenner D, Dhar D, Vallon V.

Nephron. 2020;144(8):400-412. doi:10.1159/000508636. Epub 2020 Jul 6. PMID: 32629454

 

Gene knockout of the Na+-glucose cotransporter SGLT2 in a murine model of acute kidney injury induced by ischemia-reperfusion.

Nespoux J, Patel R, Zhang H, Huang W, Freeman B, Sanders PW, Kim YC, Vallon V.

Am J Physiol Renal Physiol. 2020 May 1;318(5):F1100-F1112. doi:10.1152/ajprenal.00607.2019. Epub 2020 Mar 2. PMID: 32116018

 

Renal effects of SGLT2 inhibitors: an update.

Nespoux J, Vallon V.

Curr Opin Nephrol Hypertens. 2020 Mar;29(2):190-198. doi:10.1097/MNH.0000000000000584. PMID: 31815757 Review.

 

Effect of renal tubule-specific knockdown of the Na+/H+ exchanger NHE3 in Akita diabetic mice.

Onishi A, Fu Y, Darshi M, Crespo-Masip M, Huang W, Song P, Patel R, Kim YC, Nespoux J, Freeman B, Soleimani M, Thomson S, Sharma K, Vallon V.

Am J Physiol Renal Physiol. 2019 Aug 1;317(2):F419-F434. doi:10.1152/ajprenal.00497.2018. Epub 2019 Jun 5. PMID: 31166707 

 

Gene deletion of the Na+-glucose cotransporter SGLT1 ameliorates kidney recovery in a murine model of acute kidney injury induced by ischemia-reperfusion.

Nespoux J, Patel R, Hudkins KL, Huang W, Freeman B, Kim YC, Koepsell H, Alpers CE, Vallon V.

Am J Physiol Renal Physiol. 2019 Jun 1;316(6):F1201-F1210. doi:10.1152/ajprenal.00111.2019. Epub 2019 Apr 17. PMID: 30995111

 

SGLT2 inhibition and renal urate excretion: role of luminal glucose, GLUT9, and URAT1.

Novikov A, Fu Y, Huang W, Freeman B, Patel R, van Ginkel C, Koepsell H, Busslinger M, Onishi A, Nespoux J, Vallon V.

Am J Physiol Renal Physiol. 2019 Jan 1;316(1):F173-F185. doi:10.1152/ajprenal.00462.2018. Epub 2018 Nov 14. PMID: 30427222

 

SGLT2 inhibition and kidney protection.

Nespoux J, Vallon V.

Clin Sci (Lond). 2018 Jun 28;132(12):1329-1339. doi:10.1042/CS20171298. Print 2018 Jun 29.PMID: 29954951 Review.

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