Dr. Edward Wallace

Senior Lecturer in RNA Systems Biology

Biography

Background

Dr. Wallace is a Lecturer in RNA Systems Biology in the Institute of Cell Biology at the University of Edinburgh. He started the research group in 2018, supported by a Sir Henry Dale Fellowship from The Wellcome Trust and The Royal Society.

Before that, Dr. Wallace held a Marie Curie fellowship, also at The University of Edinburgh, working with Guido Sanguinetti and Jean Beggs on co-transcriptional splicing, regulation of protein synthesis, and analysis of ribosome profiling data.

Dr. Wallace did his postdoctoral work with D. Allan Drummond, initially at Harvard University’s FAS Center for Systems Biology. He moved with the lab to the Department of Biochemistry & Molecular Biology at the University of Chicago, and added experimental capabilities to his computational training. There, he surveyed the heat-triggered movement of proteins into RNA-protein granules, and showed that these proteins are released without detectable degradation as cells recover from stress.

Dr. Wallace received his Ph.D. in Mathematics, also at the University of Chicago, in 2010, working with Jack Cowan on stochastic dynamics of biological networks. His PhD work led to a collaboration with the late Dan Gillespie – of stochastic simulation algorithm fame – addressing the derivation and scope of the “Linear Noise Approximation” for stochastic processes.

Alongside his research, Dr. Wallace is an open science advocate and teaches data literacy to scientists, working with Edinburgh Carpentries.

Qualifications

Ph.D., Mathematics, University of Chicago

Responsibilities & affiliations

Biochemical Society

RNA Society

Society for Molecular Biology and Evolution

British Mycological Society

Undergraduate teaching

Course organiser, Biology 2A: Data Exploration in Biology

Postgraduate teaching

PhD supervisor

Open to PhD supervision enquiries?

Yes

Areas of interest for supervision

See https://ewallace.github.io/about.html#join

Research summary

Systems biology

Gene expression regulation

Post-transcriptional regulation

Fungi

Quantification and modeling of biological data.

Current research interests

RNA-binding proteins and post-transcriptional regulation in fungi Evolution of RNA-binding proteins Cell wall regulation in fungi

Past research interests

Mathematical Biology

Affiliated research centres

Current project grants

Wellcome Bioimaging Technology Development award

Past project grants

Marie Skłodowska-Curie Fellowship
Sir Henry Dale Fellowship (Wellcome Trust / Royal Society)
Carnegie Trust Research Project Grant
BBSRC-NSF

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