Dr Cristina Esteves

Senior Research Scientist

Undergraduate teaching

Animal Body 4 

Biomedical Sciences - Antibiotic crisis

Veterinary Public Health 

Postgraduate teaching

MSc - Animal Biosciences

MSc - Infectious Diseases and One Health 

Open to PhD supervision enquiries?

Yes

Areas of interest for supervision

Students

PhD students

Alex Moxom

Amira Aburza

Eleanora Dall'olio

Thomas Thrower

Julia Falk

Susan Dan-Jambo

Yennifer Cortes-Araya 

 

MSc by Research/IDOH

Daina Chakma 

Berik Kaliullayev

Patrick Lennard

Hlaing Phyo

Emma Weatherall

 

other MSc programmes (since 2014)

Ishani kadu

Raunak Sinha

Katharina Grabowski

Emma Bullen-Mehta

Amanda Mayoral

Viktorija Avilkina

Yennifer Cortes-Araya

Simone Mesquita

Juan Pesantez

Lucy Dawson

 

Vet Students (since 2014)

Dana Fuller

Blake Klein

Georgina Brown

Rebecca McCall

Tim Menghini

Research summary

Research projects:

- Mesenchymal Stem/Stromal cells (MSCs) as novel tools for combating antimicrobial resistance (AMR) in companion animals (horses and dogs) and livestock (cattle)

- Developing novel stem cell approaches towards next-generation regenerative therapies

- Involvement of Mesenchymal Stem/Stromal cells in Mycobacterium infection

- Exploiting stem cell and gene editing technologies towards discovery of genetic variants important for muscle development and meat production

- Isolation and characterisation of myogenic precursor cells in pigs: towards development of an in vitro model for the study of muscle growth

 

Invited speaker

Esteves CL, Cortés-Araya Y, Hlaing P, Rink E, Aurich C, Donadeu FX  (2022) Plenary Presentation. Exploring the tissue regeneration properties of endometrial Mesenchymal Stem/Stromal Cells. International Congress on Animal Reproduction. Bologna, Italy.

Esteves, CL. (2021) Mesenchymal Stem/Stromal Cells and pericytes in domestic animals: properties and potential. Department of Veterinary Science, University of Conception, Chile.

Esteves, CL. (2021) Mesenchymal stem/stromal cells and pericytes from veterinary species. Faculty of Veterinary and Animal Sciences, University of Chile.

Esteves CL. (2019) Plenary Presentation. Mesenchymal Stem/Stromal Cells - a Novel Therapeutic Tool Against Infection. Tissue Engineering and Regenerative Medicine International Society – Europe. Rhodes, Greece.

Esteves CL. (2016) A novel method for sorting equine MSC subpopulations: isolation and characterization of pericytes and adventitial cells. Tissue Engineering and Regenerative Medicine International Society Meeting, Uppsala, Sweden.

Esteves CL, Kelly V, Bégay V, Man TY, Lillico SG, Morton NM, Leutz A, Seckl JR, Chapman KE. (2011) Dietary down-regulation of 11β-HSD1; role of C/EBPβ and Endoplasmic Reticulum Stress. UK Adipose Tissue Discussion Group, University of Cambridge, UK.

Esteves CL. (2010) Regulation of 11β-HSD1 transcription by C/EBPβ isoforms (LIP,LAP) in adipose tissue. The Roslin Institute, Edinburgh.

 

Organiser

Tissue Engineering and Regenerative Medicine International Society (TERMIS) meeting – Session chair -  Veterinary session, 2023

Tissue Engineering and Regenerative Medicine International Society (TERMIS) meeting – Organizer - Veterinary session, 2019-

 

Participant

Oral Presentations

Cortés-Araya Y, Stenhouse C, Ashworth C, Esteves CL, Donadeu FX (2019) Developmental programming of muscle progenitor cell fate by foetal growth restriction. British Society of Animal Science Annual Conference. Edinburgh, UK.

Rink E, Amilon K, Cortes-Araya Y, Esteves CL, Watson E, Aurich C, Donadeu FX. (2017) Exploring the potential of endometrial MSCs for veterinary regenerative medicine. Tissue Engineering and Regenerative Medicine European Chapter Meeting, Davos, Switzerland.

Esteves CL, Peault B, Donadeu FX. (2016) Characterization and regenerative potential of equine pericytes. The Second Havemeyer Conference on Regenerative Medicine. Bonita Springs, FL, USA.

Esteves CL. (2016) A novel method for sorting equine MSC subpopulations: isolation and characterization of pericytes and adventitial cells. Tissue Engineering and Regenerative Medicine International Society Meeting, Uppsala, Sweden.

Esteves CL. (2016) Mesenchymal stem/stromal cells, pericytes et al. The Roslin Institute Seminars. University of Edinburgh.

Esteves CL, Sheldrake T, Sawson L, Menghini T, Khan N, Péault B, Donadeu FX. (2015) Equine bone marrow and adipose tissue mesenchymal stem/stromal cells putatively derive from perivascular stem cells. Tissue Engineering and Regenerative Medicine International Society Meeting, Boston, MA, USA.

Esteves CL. (2012) Transcriptional regulation of 11β-HSD1 in adipose. University/BHF Centre for Cardiovascular Science, University of Edinburgh, UK.

Esteves CL, Róg-Zielińska EA, Kelly V, Nixon M, Seckl JR, Chapman KE. (2011) Transcriptional regulation of 11b-hydroxysteroid dehydrogenase type 1 by pro-inflammatory cytokines is mediated by C/EBPβ. The Endocrine Society’s 93rd Annual Meeting ENDO, Boston, USA.

Esteves CL. (2011) Transcriptional regulation of 11β-HSD1 – C/EBPβ, pro-inflammatory cytokines and metabolism.  University/BHF Centre for Cardiovascular Science, University of Edinburgh.

Esteves CL, Kelly V, Man TY, Seckl JR, and Chapman KE. (2010) Dietary regulation of 11b-HSD1 in adipose tissue is mediated by the C/EBPβ isoforms LAP and LIP. The Endocrine Society’s 92nd Annual Meeting ENDO, San Diego, California, USA.

Esteves CL. (2003) Aspartic proteinases: action on milk. Department of Biochemistry, University of Coimbra, Portugal.

Esteves CL, Lucey JA, Pires E. (2001) Rheological properties of rennet-induced gels made from coagulants of vegetable origin and chymosin. Annual meeting of the American Dairy Science Association. Indianapolis, Indiana. USA. Journal of Dairy Science Abstracts (suppl 1) 84:85

 

Posters

Appleby B, Paterson G, Donadeu FX, Esteves CL (2021) Mesenchymal Stem Cells as Novel Tools for Combating Antimicrobial Resistance in Dogs. Research Student Day. The Roslin Institute, Edinburgh, UK.

Thrower T, Dan-Jumbo S, Lillico S, Esteves CL, Donadeu FX (2021) Exploiting stem cell and gene editing technologies towards discovery of genetic variants important for muscle development and meat production. Research Student Day. The Roslin Institute, Edinburgh, UK.

Dan-Jumbo SO, Cortes-Araya Y, Esteves CL, Davey M, Lillico S, Donadeu FX (2021) Isolation and characterisation of myogenic precursor cells in pigs: towards development of an in vitro model for the study of muscle growth. Research Student Day. The Roslin Institute, Edinburgh, UK.

Falk J, Esteves CL, Farquharson C, Benchoua A, Suruge P, Donadeu FX (2021) Developing novel stem cell approaches towards next-generation regenerative therapies. Research Student Day. The Roslin Institute, Edinburgh, UK.

Dan-Jumbo SO, Cortes Y, Lillico S, Esteves CL, Donadeu FX. (2020) Isolation and characterisation of myogenic precursor cells in pigs: towards development of an in vitro model for the study of muscle growth and development. The British Society for Animal Science meeting, Nottingham.

Weatherall E, Alvinika V, Black K, Cortes-Araya Y, Dan-Jumbo S, Stenhouse C, Donadeu FX, Esteves CL (2020) Mesenchymal Stem/Stromal cell (MSC) tissue regeneration potential may be developmentally programmed. Society for Reproduction and Fertility - Fertility 2020 meeting. Edinburgh, UK.

Developmental programming of porcine muscle progenitor cell fate by foetal growth restriction (FGR). Society for Reproduction and Fertility - Fertility 2020 meeting. Edinburgh, UK.

Dan-Jumbo SO, Cortes Y, Esteves CL, Davey M, Lillico S, Donadeu FX. (2019) Investigating the effects of intrauterine growth restriction (IUGR) on myogenic and adipogenic progenitor cell populations in pigs. Research Student Day. The Roslin Institute, Edinburgh, UK.

Cortés-Araya Y, Stenhouse C, Ashworth C, Esteves CL, Donadeu FX. (2019) Developmental programming of porcine muscle progenitor cell fate by foetal growth restriction. Research Student Day. The Roslin Institute, Edinburgh, UK.

Mohammed BT, Esteves CL, Donadeu FX. (2019) Isolation of different bovine luteal cell fractions using. Society for Reproduction and Fertility - Fertility 2019 meeting. Birmingham, UK.

Weatherall E, Cortes Y, Donadeu FX, Esteves CL. (2018) Characterization of porcine adipose Mesenchymal Stem/Stromal Cells (MSCs) in Intrauterine growth restriction. Adipose Tissue Discussion Group meeting. The University of Edinburgh, Edinburgh, UK.

Cortes Y, Amilon K, Stenhouse C, Ashworth C, Esteves CL, Donadeu FX. (2018) Developmental programming of muscle stem cell fate by intrauterine growth restriction (IUGR). Society for the Study of Reproduction. New Orleans, USA.

Weatherall E, Cortes Y, Donadeu FX, Esteves CL. (2018) Characterisation of Mesenchymal Stem/Stromal cells (MSCs) and Pericytes from Porcine Adipose Tissue; The Effects of Intrauterine Growth Restriction. Research Student Day. The Roslin Institute, Edinburgh, UK.

Dan-Jumbo S, Cortes Y, Esteves CL, Davey M, Donadeu FX. (2018) Programming of myogenic and adipogenic progenitor cells in utero by Intrauterine growth restriction (IUGR) in pigs. Research Student Day. The Roslin Institute, Edinburgh, UK.

McCall R, Donadeu FX, Esteves CL. (2017) Effects of Intrauterine growth retardation on adult stem cell development in pigs. Vet Choice. Veterinary Research Program, Royal (Dick) School of Veterinary Studies, University of Edinburgh, UK.

*Cortes Y, Amilon K, Stenhouse C, Adesina O, Ashworth C, Esteves CL, Donadeu FX. (2017) The effects of intrauterine growth restriction (IUGR) on muscle development in pigs -towards novel targets to improve pig production. Student Day. The Roslin Institute, Edinbugrh, UK. *poster competition - 2nd prize

Amilon KR, Cortes YA, Mendonca C, Fitzgerald JR, Donadeu FX, Esteves CL. (2016) Antibacterial effects of equine mesenchymal stem cells. Tissue Engineering and Regenerative Medicine International Society Meeting, Uppsala, Sweden.

Esteves CL, Sheldrake T, Sawson L, Menghini T, Khan N, Péault B, Donadeu FX. (2015) Equine mesenchymal stem/stromal cells putatively derive from perivascular stem cells. Annual meeting of the International Society for Stem Cell Research, Stockholm, Sweden.

Rink E, French H, Watson E, Aurich C, Esteves CL, Sheldrake T, Donadeu FX. (2015) Equine endometrial mesenchymal stromal/stem cells: isolation, culture and gene expression profiles. Annual meeting of the International Society for Stem Cell Research, Stockholm, Sweden.

Rink E, French H, Watson E, Aurich C, Esteves CL, Sheldrake T, Donadeu FX. (2015) Isolation and culture of equine endometrial mesenchymal stromal cells. 48th Annual Meeting the Society for the Study of Reproduction (SSR), Puerto Rico, USA.

Menghini T, Dawson L, Esteves CL, Donadeu FX. (2014) Localisation and characterisation of mesenchymal stem cells in equine tissues. Vet Choice. Veterinary Research Program, Royal (Dick) School of Veterinary Studies, University of Edinburgh, UK.

Zhang Z, Esteves CL, Turban S, Manwani K, Brown O, Man T-Y, Seckl JR, Chapman KE. (2013) Tissue-specific knock-out of 11β-HSD1 affects adipocyte size and fibrosis in mice with diet-induced obesity. Young Life Scientists' Symposium 2013: Cardiovascular Medicine: Bridging clinical and basic researchers, British Pharmacological Society, London.

Esteves CL, Schauer S, Sontake S, Donadeu FX. (2013) Profiling of miRNA regulators of granulosa cell function during follicle development on mares. Society for the Study of Reproduction 46th annual meeting, Montreal, Canada.

*Coutinho AE, Kipari T, Zhang Z, Esteves C, Gilmour JS, Cailhier J-F, Hughes J, Seckl JR, Savill JS, Chapman KE. (2011) Dynamic regulation of 11b-hydroxysteroid type 1 in neutrophils during an inflammatory response. The Endocrine Society’s 93rd Annual Meeting ENDO, Boston, USA. *poster competition -1st prize  

Esteves CL, Róg-Zielińska EA, Kelly V, Nixon M, Seckl JR, Chapman KE. (2010) Transcriptional regulation of 11b-hydroxysteroid dehydrogenase type 1 by pro-inflammatory cytokines. UK Adipose Tissue Discussion Group, University of Oxford, UK.

*Esteves CL, Kelly V, Man JY, Lillico SG, Morton NM, Seckl JR, Champan KE. (2010) The C/EBPb isoforms, LIP and LAP, mediate dietary regulation of 11b-HSD1 in mouse adipose tissue. Cardiovascular Development/Stem Cells Workshop and Centre for Cardiovascular Science Symposium day, University of Edinburgh, UK. * poster competition -2nd prize

Esteves CL, Kelly V, Man JY, Lillico SG, Morton NM, Seckl JR, Champan KE. (2010) The C/EBPb isoforms mediate the down-regulation of 11b-HSD1 in mouse adipose tissue fed high-fat diet. Diabetes and obesity: getting to the heart of the matter. The Royal Society of Edinburgh, UK.

*Esteves CL, Kelly V, Man JY, Seckl JR, Champan KE. (2009) Relative levels of the C/EBPb isoforms, LAP and LIP, may underpin high fat diet down-regulation of 11b-HSD1 in mouse adipose tissue. Adipose Tissue Discussion Group Meeting. AstraZeneca, Macclesfield, UK. * poster competition -1st prize

Esteves CL, Morton NM, Seckl JR, Champan KE. (2008) C/EBP isoforms and 11b-HSD1 levels are altered in the adipose tissue of obese mice. Centre for Cardiovascular Science Symposium Day. University of Edinburgh, UK.

Esteves CL, Morton NM, Seckl JR, Champan KE. (2008) Differential changes in C/EBP isoforms may underpin tissue-specific dysregulation of 11b-HSD1 with high fat feeding. Society for Endocrinology BES 2008 Meeting. Harrogate, UK.

Esteves CL, Morton NM, Seckl JR, Champan KE. (2007) Is there a role for C/EBP transcription factors in 11b-HSD1 regulation in obesity? Centre for Cardiovascular Science Symposium Day, University of Edinburgh, UK.

Esteves CL, Jones B, Clegg S. (2004) Biofilm formation in mixed infections of Salmonella enterica Serovar Typhimurium and Escherichia coli on epithelial cells. American Society for Microbiology 104th General Meeting. New Orleans, USA.

Esteves CL, Jones B, Clegg S. (2003) Biofilm formation of Salmonella enterica serovar Typhimurium and Escherichia coli. Midwest Microbial Pathogenesis Conference. Iowa City, USA.        

Esteves CL, Lucey JA, Pires E. (2003) Effect of pH of milk on gels produced by plant coagulants and chymosin. Institute of Food Technologists Annual Meeting. Chicago, USA.

Esteves CL, Lucey JA, Hyslop, DB, Pires E. (2002) Effect of temperature on the gelation properties of rennet-induced gels made from plant coagulants and chymosin. 26th International Dairy Congress. Paris, France.

Esteves CL, Lucey JA, Gunasekaran S, Pires E. (2000) Rheological evaluation of milk gels formed with chymosin and vegetable rennets. Institute of Food Technologists Annual Meeting. Dallas, USA.

Esteves C, Gunasekaran S, Olson N, Pires, E. (1999) Rheological Characterization of Milk Gelation Using Vegetable Coagulants and Chymosin. The Society of Rheology 71th Annual Meeting. Madison, USA.

Esteves C, Pereira A, Schultz J, Pires E. (1998) Two Mediterranean Vegetable Rennets - Ability to Coagulate Cow Milk. 25th International Dairy Congress. Aarhus, Denmark.

Veríssimo P, Ramalho-Santos M, Esteves C, Faro C, Pires E. (1996) A comparative study on the aspartic proteinases from different species of Cynara.  X Congresso Nacional de Bioquímica. Universidade do Minho, Braga, Portugal.

Esteves CL, Veríssimo PC, Faro CJ, Pires EV. (1995) Biochemical characterization of the vegetable rennets from the flowers of cardoon: comparison to calf rennet. 1995 Annual meeting of American Dairy Science Association. Cornell University, Ithaca, New York, USA.

MSc Curriculum Developer/Coordinator

Programme Advisor for Gujarat Biotechnology University (GBU)

 

Panel Member 

The Foundation for Science and Technology (FCT), Animal and Veterinary Sciences and Agro-Food Biotechnology- Individual Call to Scientific Employment Stimulus, Portugal 

 

Research Proposals Reviewer

MITACS, Canada.  Research proposal reviewer 

 

PhD Thesis - International external referee

Department of Physiology and Biochemistry of Animal Nutrition, University of Granada, Spain. (2022)

 

Editor

Associate Editor, Frontiers in Veterinary Science, Veterinary Regenerative Medicine,  2021-

Guest Editor, Frontiers in Veterinary Science, Veterinary Regenerative Medicine – Women in Science , 2022

Reviewer Board, Animals, 2021-

Review Editor, Frontiers in Veterinary Science - 2015-2021

 

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