Dr Charis Wong (MBChB (Hons.), MRCP (Neurology), PhD)
Honorary Senior Clinical Lecturer
- Centre for Clinical Brain Sciences
- Euan Macdonald Centre for Motor Neuron Disease Research
- Anne Rowling Regenerative Neurology Clinic
Contact details
- Email: charis.wong@ed.ac.uk
Background
Charis is a consultant neurologist at NHS Fife and Honorary Senior Clinical Lecturer with the CAMARADES group at the University of Edinburgh. She is interested in developing methodology to systematically identify, evaluate and report evidence to improve drug selection for clinical trials. She studied medicine at the University of Edinburgh. She underwent clinical training, including neurology specialty training, across various hospitals within South East Scotland. She joined the Anne Rowling Clinic as a Clinical Trial Fellow in 2019. She was part of the trial development group for MND-SMART (mnd-smart.org), a multi-arm multi-stage clinical trial in motor neuron disease (MND). She undertook a PhD supervised by Professor Malcolm Macleod, Professor Siddharthan Chandran, and Professor Neil Carragher where she developed methods for systematic multimodal evidence-based drug prioritisation for MND clinical trials. She is continuing to develop this work with the aim of improving the framework and expanding its applications to other disease areas (currently including cerebral small vessel disease, intracerebral haemorrhage, progressive multiple sclerosis and Alzheimer’s disease). She is also interested in evaluating AI-enabled digital evidence synthesis tools and systematic review platforms.
Qualifications
PhD (2024)
"Developing a systematic, data-driven framework to identify, evaluate, and prioritise candidate drugs for clinical trials in motor neuron disease"
Supervised by Professor Malcolm Macleod, Professor Siddharthan Chandran and Professor Neil Carragher
Specialty Certificate Examination in Neurology
Member of the Royal College of Physicians (UK)
Bachelor of Medicine and Bachelor of Surgery (MBChB) with Honours, University of Edinburgh.
Research summary
Neurodegenerative diseases are disabling, progressive neurological diseases. Despite decades of research, there is a lack of effective treatments to slow, stop or reverse these diseases. Charis is studying ways we can use different types of data to improve how drugs are selected for clinical trials in neurodegenerative diseases, in particular motor neuron disease. To this end, she developed the Systematic Living Evidence for Clinical Trials (SyLECT) framework (https://osf.io/7mza9), a modular, multi-modal, data-driven framework to guide drug selection for clinical trials, and have successfully applied this to inform drug selection for MND-SMART (https://mnd-smart.org/, NCT04302870). MND-SMART is a multi-arm, multi-stage, adaptive platform trial evaluating drugs in motor neuron disease/amyotrophic lateral sclerosis. Currently, the framework uses data from:
(i) published studies of various neurodegenerative diseases via the Repurposing Living Systematic Review-Motor Neuron Disease (ReLiSyR-MND; https://camarades.shinyapps.io/ReLiSyR-MND/),
(ii) experimental drug screening including in house high throughput phenotypic drug screening,
(iii) pathway and network analysis,
(iv) mining drug, chemical and trial databases, and
(v) expert opinion.
She is currently working on improving this framework and to expand its applications to other disease areas.