Dr. Alejandro J. Brenes
Wellcome Early Career Fellow - Neutrophil Single Cell Proteomics
- Centre for Inflammation Research
- Institute for Regeneration and Repair
Contact details
- Email: abrenes@ed.ac.uk
- Web: Google Scholar Profile
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Address
- Street
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5 Little France Dr
- City
- Edinburgh
- Post code
- EH16 4UU
Background
Alejandro graduated from his PhD at the University of Dundee in 2023 under the supervision of Prof. Cantrell and Prof. Lamond. His work focussed on using large-scale proteomics and computational biology to characterise the murine and human immune system, with a focus on murine T cells and human neutrophils. This led him to create the Immunological Proteome Resource (immpres.co.uk).
In 2024 Alejandro started working as a postdoctoral computational biologist within the Walmsley Group at the Centre for Inflammation Research, part of the University of Edinburgh. His research is now focussed on the proteomic characterisation of human granulocytes by leveraging mini-bulk and single cell proteomic workflows with the aim to define neutrophil and granulocyte functional heterogeneity, functional capacities and phenotypes in both homeostasis and chronic inflammatory disease.
In November 2025 he was awarded a Wellcome Trust Early Career Award to carry out his independent research to define neutrophil functional heterogeneity & dysfunction in chronic obstructive pulmonary disease (COPD) using single cell proteomics.
Responsibilities & affiliations
British Society for Proteome Research Management Committee
British Mass Spectrometry Society
British Society for Immunology
Research summary
Alejandro's research area is systems immunology and proteomics. He aims to leverage cutting edge mass spectrometry-based proteomics methods, including mini-bulk and single cell proteomics, combined with computational and AI developments in order to characterise human granulocytes in health and chronic inflammatory disease.
Alejandro's research interest also focus on open data and data sharing, making proteomics data easily available as a community resource. He is the creator and maintainer of the Immunological Proteome Resource (http://immpres.co.uk/).
Current research interests
Expanding single cell proteomic workflows to study human neutrophils in health and chronic inflammatory disease, with current emphasis on chronic obstructive pulmonary disease.Affiliated research centres
Project activity
Defining neutrophil functional heterogeneity & dysfunction in chronic obstructive pulmonary disease (COPD) using single cell proteomics
Current project grants
Wellcome Trust Early Career Award
Invited speaker
British Society for Matrix Biology Meeting (2025)
6th European Symposium on Single Cell Proteomics (2025)
Festival of Genomics and Biodata - London (2025)
11th in-person Lodon Proteomics Discussion Group Symposium (2024)
5th European Symposium on Single Cell Proteomics (2024)
Scottish Biological Mass Spectrometry Meeting (2023)
MJ Dunn Fellowship (2025)
Poster Prize - British Society for Proteome Research Symposium (2025)
Poster Prize - BMSS & BSPR Super meeting (2024)
Early Career Award - British Society for Proteome Research & European Proteomics Association (2023)
Early Career Award - British Society for Proteome Research (2022)