Post-doctoral research fellow
Address
- Street
-
Chancellor's Building
49 Little France Crescent
- City
- Edinburgh
- Post code
- EH16 4SB
Current research interests
Blood-brain barrier (BBB) disruption occurs in aging and is associated with dementia. Endothelial cells and pericytes are closely associated actors of the brain vasculature. Dysfunctions of both cell types have been evidenced in aging and dementia, though the precise mechanisms leading to BBB disruption are unknown. In the Montagne Lab, I am investigating the interplay between pericytes and endothelial cells in a variety of in vivo models, with MRI, PET and 2-photon imaging.
An associated consequence of aging is the swelling of perivascular spaces, described as a route for brain waste drainage. A second part of my project focuses on this transformation and its relations with BBB disruption.
