Aoife Giblin
Thesis title: Development of deubiquitinase-targeting chimeras (DUBTACs) for stabilisation of PDE4 to treat patients with high risk, androgen resistant prostate cancer
MRC Precision Medicine Doctoral Training Programme
Year of study: 1
- School of Cardiovascular and Metabolic Health
- University of Glasgow
Contact details
- Email: a.giblin.1@research.gla.ac.uk
- Web: LinkedIn
PhD supervisors:
Address
- Street
-
Wolfson Link
West Medical Building - City
- Glasgow
- Post code
- G11 6PB
Background
I am in my first year of the Precision Medicine doctoral training programme, funded by the Medical Research Council. My project, in collaboration with Katalytic Therapeutics, aims to assess the viability of stabilising the level of longform phosphodiesterases using DUBTAC compounds in order to treat high-risk non-androgenic prostate cancers.
Qualifications
MSci Pharmacology
Research summary
Cancer sciences, pharmacology, cell signalling, precision medicine and molecular biology
Affiliated research centres
Sin, Y. Y. et al. (2024) Targeted protein degradation of PDE4 shortforms by a novel proteolysis targeting chimera. FEBS Journal, 292(13), pp.3360-3377. (DOI: https://doi.org/10.1111/febs.17359)