Professor Stephen Gordon (MD FRCP)

Professor of Global Respiratory Medicine

  • Centre for Inflammation Research
  • Institute of Repair and Regeneration
  • University of Edinburgh

Contact details

Address

Street

Institute for Regeneration and Repair
Edinburgh BioQuarter,
4-5 Little France Drive,
Edinburgh

City
Edinburgh BioQuarter
Post code
EH16 4UU

Biography

Open to PhD supervision enquiries?

Yes

Research summary

Translational clinical research leading to impact in low and middle income countries.

Respiratory Infection

Current research interests

Controlled human infection models to demonstrate vaccine effiacacy.

Past research interests

Household air pollution. HIV effects on the lung.

Affiliated research centres

Project activity

We use Controlled Human Infection Models of pneumococcal disease to understand protection from colonisation and infections.  Current studies include

  • Pneumococcal Conjugate Vaccine efficacy studied by Controlled Human Infection Model (PCV13-CHIM)
  • Pneumococcal protein vaccine (PBV-CHIM)
  • Pneumococcal type 3 model (SPN3)
  • Controlled human infection models in people living with HIV (EPOCH)
  • Advanced CHIM acceptability (ACHIMA)

We also study severe infections and clinical intervention in the hospital.  Current studies include

  • Understanding use of oxygen in the hospital, and the means to improve it (Pre-BREATHE)
  • A clinical trial of standard flow vs high flow oxygen to improve outcome in patients admitted with hypoxia (BREATHE)

Current project grants

UKRI - MRC DPFS Stephen Gordon (PI). Efficacy trial of PnuBioVax vaccine against serotype3 Streptococcus pneumoniae in a controlled human challenge model in Malawi (PBV-CHIM) £3,200,000 2024-2027
Wellcome Translation. Collaboration Dr Beth Riviello BREATHE– trial of high-flow oxygen in hypoxic adults $441,439 (and further funding now confirmed to end 2026) 2022-2024
Wellcome Discretionary Award (Vaccines). Stephen Gordon (PI) Malawi Accelerated Research in Vaccines, Experimental and Laboratory Systems (MARVELS) £4,447,903 2018-2025
Wellcome: Core Award for the Malawi Liverpool Wellcome Trust Programme £25,084,066 2018-2023
Wellcome: Core Award Extension for the Malawi Liverpool Wellcome Trust Programme £9,884,066 2023-2025
Wellcome, Univ of Liverpool and LSTM: Clinical Research Excellence and Training Open Resource (CREATOR) £8,450,000 2021-2025

Past project grants

PATH: COVID Vaccine Preparedness (built Research Pharmacy) $441,439 2020-2021
Wellcome: COVID Extraordinary Provision (Oxygen plant, PPE and public engagement to impact Malawi survival during pandemic) £2,100,000 2020-2021
Wellcome: Physiological responses to fluid resuscitation in sub-Saharan African adults with sepsis (Fellowship Jamie Rylance) £813,093.00 2018-2021
MRC Expt Med: (Collaboration Jerry Brown, UCL) Enhancing mucosal immunity to Streptococcus pneumoniae by nasal administration of live strains attenuated in virulence £ 533,934 2017-2020
MRC Programme: (Stephen Gordon PI) Experimental Human Pneumococcal Carriage to determine optimal protection from carriage and mechanisms of mucosal immunization against disease £2,295,295 2015-2020
MRC Translational Award: £599,790
Bill and Melinda Gates Foundation: (Co-PI, Daniela Ferreira) Live Attenuated Influenza Vaccine and Trivalent Influenza Vaccine effect on density and duration of Expt Human Pneumococcal Carriage $2,518,294 2014-2017

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